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Titres et travaux scientifiques
Massoud MIRSHAHI: M. D., Ph.D, French nationality, Researcher in CNRS (1986- p), Professor of oncology (2009-p), Academician (2002) (FM), Co-head of Regenerative Medicine in Avicenna University, Dushanbe (Tajikistan 2009-p), Several patents and licenses for industrial exploitation, several scientist awards such as Immunopathology of the Eye, Tokyo Japan, 1986, American College of Toxicology » 2002, Pennsylvania, USA, Prize of “Institut de France” (Prix Dalloz), 2006, Paris, south Korea cancer institute 2017, over 200 international scientific publications, 290 congress communications. Editor en chef for several scientific journal, Reviewer in several International Journals such as in Oncology, immunology and Ophthalmology fields. Member of several International Academic Associations, Thesis director of more than 20 thesis, as well as several postgraduate students, Masters, and postdoctoral students. Obtaining of research grants from several local associations, French or foreign industries and foundations. Main research specialty is: cancerology, immunology, fibrinolysis, thrombosis and coagulation, ocular immunopathology, principal activity: role of the microenvironment in cancer cell proliferation, metastasis and resistance to therapy. Discovery of a tumor micro-environmental cell (named Hospicell) protecting cancer cells from chemotherapy by different mechanisms. Stem cell therapy for heart regenerative medicine and target therapy in cancer disease.
Key words: Arrestin, Plasminogen Activators, Fibrin-Fibrinogen, Thrombosis, D-Dimer, Autoimmune-Disease, Mineralocorticoid Receptor (MCR), Epithelial Sodium Channel (Enac), Ophthalmology (Retina And Cornea), Cancer, Angiogenesis, Chemoresistance, Leukemia, Bone Marrow Stromal Cells, Hospicell, Biomaterial, Nanoparticle, Radio-Frequency Plasma, Mesenchymal Cells, Stem Cells, Regenerative Medicine, Carcinomatosis. Personalized Medecine. Cancer and Thrombosis, Immunology of Cancer, HLA-G.
CURRICULUM VITAE
Massoud MIRSHAHI
Né le 19 Mai 1954 à Nishabour (Iran)
Nationalité : Française, marié, deux enfants
Titres : Docteur, Professeur, Academicien
Diplôme :
- DERBH en Physiologie et Biochimie de l'hémostase
(Pr. Caen -Faculté de Médecine de Paris VII), 1987.
- Doctorat d'Etat en Science de Biologie Humaine [immunologie]
(Pr. Seligman Faculté de Médecine de Paris VII), 1986
- Doctorat en Médecine.
(Pr Hemker, Université de Limbourg, Holland), 1984
- AEA de Physiologie et Biochimie de l'hémostase
(Pr. Caen Faculté de Médecine de Paris VII), 1984
- AEA d'Immunogénétique et Transplantation, Immunopathologie
(Pr. Seligeman Faculté de Médecine de Paris VII),1984
- Certificat d'Etudes Supérieures d'Immunologie Générale
(Pr. Homberg -Faculté de Médecine de Paris VI), 1983
- Certificat d'Etudes Supérieures en Cancérologie Générale et expérimentale
(Pr. Mathé-Faculté de Médecine de Paris XI), 1983
Activités :
Autres activités :
Membre des sociétés scientifiques :
Bourse et Prix Scientifiques :
Subventions et contrats divers :
Direction et contribution à des thèses et mémoires
de Maîtrise et DEA, Master 1 et 2
Thèse :
Thèse de Doctorat en Sciences, Paris XI
Thèse de Doctorat en Sciences, Paris VI
Thèse de Doctorat en Sciences, Université de Navarra, Espagne (Co-Direction).
Thèse de Doctorat en Sciences, Paris VI.
Thèse de Doctorat en Sciences, Université de Monastir, Tunisie
Thèse de Doctorat en Sciences, Université de Rouen. (Co-direction)
Thèse de Doctorat en Sciences, Paris XI
Thèse de Doctorat en Sciences, Paris XI
Thèse de Doctorat en Sciences, Université de Monastir, Tunisie (Codirection).
Thèse de Doctorat en Sciences, Paris XI (16 septembre 2011)
Thèse de Doctorat en Sciences, Paris XI (18 novembre 2011)
Thèse de Doctorat en Sciences, Paris XI (06 décembre 2012)
Thèse de Doctorat en Sciences, Paris XI (21 décembre 2012)
Thèse de Doctorat, (ecole doctoral de Cancerologie, Paris Sud), Septembre 2015, (Co Direction avec Univesité de Monastir, Tunisie)
Thèse de Doctorat, (ecole doctoral de Cancerologie, Paris-saclay), Novembre 2015, (Co Direction avec Branche de l’Université de Cornell, New york, Doha-Qatar).
Thèse de Doctorat,(ecole doctoral de Cancerologie,Paris -Saclay), Novembre 2015, (Co Direction avec Branche de l’Université de Cornell, New york, Doha-Qatar).
D’autres theses :
Thèse de l’Ecole pratique des hautes études, Paris, (Codirection)
Thèse de Doctorat en Sciences, Paris VI, (Codirection)
Thèse de Doctorat en Sciences, Paris VI, (Codirection)
Thèse de doctorat, faculté de Médecine, Berlin, Allemagne,
Diplôme d’Etudes Doctorales, Université de Rouen. (Codirection).
DEA et Master-2
DEA Différentiation, Génétiques et immunologie, Lyon.
DEA Structure et fonction des systèmes biologiques intégrés, Paris XI
DEA Biologie moléculaire et cellulaire végétale, Paris XI.
Master-2, Biologie cellulaire et moléculaire, Paris VI
Master-2, Cancérologie, Paris XI
Master 2, Biologie Moléculaire et Biochimie, Paris VI.
Master 2, Biologie Intégrale, Versailles.
Master 2, Santé Mention Biologie Cellulaire, Paris V
Master 2, Pharmacologie et thérapie anti tumorale, Paris XI.
Master 2, Université paris V.
Master 2, Université Paris VI.
Master 2, Université Paris V.
Master-2, Mention Sciences Biomédicales, Spécialité Physiologie (Université de Rouen)
Master-2 sciences chirurgicales, parcours cancérologie. (Université Paris-Est, Créteil Val de Marne)
Master-2 Sciences Chirurgicales option cancérologie 2015-2016, (Université Paris XI).
Master -2 de sciences chirurgicales parcours cancérologie, (Université Paris-Est, Créteil Val de Marne)
Master -2 de sciences chirurgicales parcours cancérologie, (Université Paris-Est, Créteil Val de Marne).
Master-2, Recherche phalmacologie intégrée préclinique et clinique, Université Paris Descartes.
Master-2, Recherche phalmacologie intégrée préclinique et clinique, Université Paris Descartes.
Master 1
Master 1 Sciences et Santé, Paris XIII
Master 1 Sciences et Santé, Paris XIII
Master-1, GCDE, Paris XI
Master 1, Santé Mention Biologie Cellulaire, Paris V
Licence
Licence de Biologie intégrée, Université Cergy Pontoise
Licence, (Université Paris Sud- saclay)
Devenir des étudiants
Collaborations national et Internationale
Depuis mon intégration au CNRS, j’ai eu différents contacts nationaux et internationaux avec qui j’ai réalisé certaines expériences qui m’ont permis d’établir des concepts physio-pathologiques. Il s’agit de ces différents collaborateurs dont l’appartenance citée était celle du moment de la collaboration :
Gregerson Univ. Minneapolis, O. Bertrand, INSERM U 160, Hôpital Beaujon. I. Gery, NIH, Bethesda, R. Stiemer, à l'EMBL, Heidelberg, G. Collenot, Université de Paris VI,
D. Hicks INSERM, Strasbourg, H. Hamm, Chicago University, C. Haye, Institut Curie,
P. Dhermy, Hôtel-Dieu, Paris, MM. Ruchoux de CHU de Lille, B. Pessac ,CNRS, Ivry, H. Kühn, de l'Université de Jülich, Allemagne, M. Chabre et C. Pfister ,CNRS, CEA, Grenoble, J.-P. Collin CNRS URA 290, Université de Poitiers, J. Grassi ,CEN, Saclay, J. Y Perrot Hôtel Dieu de Paris, C. Soria, Université de Rouen, J. Oliver et G. Gabrion,CNRS URA 1197, Université de Montpellier II, E. Schuller, INSERM U 134, Hôpital de la Salpêtrière Paris, R. Motais, CNRS URA 638, CEA, Villefranche sur Mer, M. Kazatchkine et J. Bariéty Broussais Université Paris VI, Paris , D. Barritault, A. Vandewalle, INSERM U 246, A. Nato, CNRS URA 1128, Université de Paris XI, Orsay, A. Trémollières, B. Pineau, CNRS, Gif-sur-Yvette, CNRS, Y. Henry, J. De Buyser, CNRS, Univ Paris XI, Orsay, M. Kreiss, CNRS, Univ Paris XI, Orsay. J.P. Carde, CNRS, Univ. Bordeaux 1. P.Burtin CNRS, Villejuif, S. Fermandjian à l'Institut Gustave Roussy M. Poupot, E. Mery Hôpital Purpan, Toulouse, B. Couderc , Institute Claudius Rigout, Toulouse, C. Soria, Faculté de Pharmacie, Rouen, C. Roisse CEA ST. Louis, A. Rafii, Cornell, USA, branche Qatar, JP Collet, Hôpital pitié salpêtriers, I. Ghedira, Hôpital de Sousse, Tunisie, N. Sakly, Faculté de Pharmacie, Monastir, Tunisie. JM Legeais, Hôtel Dieu de Paris, L. Garderet, Hôpital St.Antoine, Sh. Rafii, Cornell, New York, USA. Z. Michal, Luminy, Marseille. U. Kurbanov, Avicenna University, Tadjikistan. France : LISE-UMR 8235-UPMC: Pr. F. Arefi-Khonsari, Corée du Sud: Institut National du Cancer, Pr San Song, Université de Séoul, Consortium ‘International Society of Precision Cancer Medicine ISPCM, 2018-p’.
Publications
ARTICLES
[1] Boucheix C, Perrot JY, Mirshahi M, Rosenfeld C. A rapid method for the detection of membrane antigens by immunofluorescence and its application to the screening of hybridoma antibodies.
J. Immunol. Methods, 1983, 57, 145-150.
[2] Boucheix C, Soria C, Mirshahi M, Soria J, Perrot JY, Fournier N, Billard M, Rosenfeld C. Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (Acute Lymphoblastic Leukemia Antigen P 24). Inhibition of aggregation by ALB6 Fab.
FEBS Lett. 1983, 161, 289-295.
[3] Faure JP, Mirshahi M, Dorey C, Thillaye B, de Kozak Y, Boucheix C. Production and specificity of monoclonal antibodies to retinal S-antigen.
Curr. Eye Res. 1984, 3, 867-872.
[4] Mirshahi M, Faure JP, Brisson P, Falcon J, Guerlotté J, Collin JP. S-antigen immunoreactivity in retinal rods and cones and pineal photosensitive cells.
Biol. Cell, 1984, 52, 195-198.
[5] Pfister C, Dorey C, Vadot E, Mirshahi M, Deterre P, Chabre M, Faure JP. La protéine dite "48K" qui interagit avec la rhodopsine illuminée dans les batonnets rétiniens identifiée avec l'"antigène S rétinien" inducteur de l'uvéo-rétinite auto-immune expérimentale.
C.R. Acad. Sci. (Paris), 1984, 299, 261-265.
[6] Perrot JY, Boucheix C, Mirshahi M, Kazatchkine M, Bariéty J. Des anticorps monoclonaux dirigés contre des antigènes de surface de lymphoblastes et de cellules sanguines ou médullaires reconnaissent des constituants du néphron humain.
Néphrologie, 1984, 5, 53-57.
[7] Altério J, Dorey C, Mirshahi M, Faure JP, Barritault D. S-antigen is coded by poly (A)+ mRNA from bovine retina. Biochem. Biophys. Res. Comm., 1985, 132, 934-938.
[8] Boucheix C, Perrot JY, Mirshahi M, Giannoni F, Billard M, Bernadou A, Rosenfeld C. A new set of monoclonal antibodies against acute lymphoblastic leukemia.
Leukemia Res., 1985, 9, 597-604.
[9] Cook J, Fischer G, Boucheix C, Mirshahi M, Jouvin MH., Weiss L, Jack RM., Kazatchkine M.D. Mouse monoclonal antibodies to the human C3b receptor.
Molecular Immunology, 1985, 22, 531-539.
[10] de Kozak Y, Mirshahi M, Boucheix C, Faure JP. Inhibition of autoimmune uveoretinitis by monoclonal antibodies.
Eur. J. Immunol., 1985, 15, 1107-1111.
[11] de Kozak Y, Mirshahi M, Sainte-Laudy J, Thillaye B, Faure JP. Experimental autoimmune uveoretinitis in athymic rats: specific IgE response to retinal S-antigen and disease.
Immunol. Lett., 1985, 9, 109-115.
[12] Enouf J, Bredoux R, Boucheix C, Mirshahi M, Soria C, Levy-Toledano S. Possible involvement of 2 proteins (phosphoprotein and CDS (P 24) in regulation of platelet calcium fluxes.
FEBS Lett., 1985, 398-402.
[13] Mirshahi M, Boucheix C, Collenot G, Thillaye B, Faure JP. Retinal S-antigen epitopes in vertebrate and invertebrate photoreceptors.
Invest. Ophthalmol. Vis. Sci., 1985, 26, 1016-1021.
[14] Soria J, Soria C, Borg JY, Mirshahi M, Piguet H, Tronc C, Fressard C, Caen JP. Platelet aggregation occurs in congenital afibrinogenemia despite the absence of fibrinogen or its fragments in plasma and platelets demonstrated by immunoenzymology.
Brit. J. Haematol., 1985, 60, 503-514.
[15] Soria J, Soria C, Mirshahi M, Samama M. Markers of fibrinogen derivatives used in clinical investigation.
Seminars in Thrombosis, 1985, 11, 129-132.
[16] Soria J, Soria C, Mirshahi M, Boucheix C, Aurengo A, Perrot JY, Bernadou A, Samama M, Rosenfeld C. Conformational change in fibrinogen induced by adsorption to a surface.
J. Colloid and Interface Science, 1985, 107, 204-208.
[17] Collin JP, Mirshahi M, Brisson P, Falcon J, Guerlotté J, Faure JP. Pineal-retinal molecular relationships; distribution of "S-antigen" in the pineal complex.
Neuroscience, 1986, 19, 657-666.
[18] Mirshahi M, Boucheix C, Dhermy P, Haye C, Faure JP. Expression of the photoreceptor specific S-antigen in human retinoblastoma.
Cancer, 1986, 57, 1497-1500.
[19] Mirshahi M, Soria J, Soria C, Perrot JY, Boucheix C. A latex immuno-assay of fibrin/ogen degradation products in plasma using a monoclonal antibody.
Thrombosis Res., 1986, 44, 715-728.
[20] de Kozak Y, Mirshahi M, Boucheix C, Faure JP. Prevention of experimental autoimmune uveoretinitis by active immunization with autoantigen-specific monoclonal antibodies.
Eur. J. Immunol., 1987, 17, 541-547.
[21] de Kozak Y, Mirshahi M, Faure JP.
Rétine et auto-immunité.
Médecine/Sciences, 1987, 3, 207-215.
[22] Mirshahi MC, Soria J, Soria C, Bertrand O, Mirshahi M, Basdevant A.
Glycosylation of human fibrinogen and fibrin in vitro. Its consequences on the properties of fibrin(ogen).
Thromb. Res., 1987, 48, 279-289.
[23] Oliver J, Herbuté S, Mirshahi M, Faure JP, Brisson P, Collin JP. Identification d'une protéine apparentée à l'Antigène S dans les plexus choroïdes de la caille.
C.R. Acad. Sci. (Paris), 1987, 105, série III, 485-491.
[24] Soria C, Mirshahi MC, Soria J, Mirshahi M, Dunnice S, Boucheix C, Beaufils R, Slama R, Caen JP. Dynamic coronary fibrinolysis evaluation in patients with myocardial infarction and unstable angina by specific plasma fibrin degradation products determination.
Thrombosis Res. 1987, 45, 383.
[25] Soria J, Soria C, Mirshahi MC, Mirshahi M, Boucheix C, Pujade E, Perrot JY, Samama M, Bernadou A, Caen JP. Un marqueur spécifique de la thrombolyse : le complexe DDE.
C.R. Acad. Sc. Paris, 1987, 304, série III, 307-311.
[26] Soria J, Soria C, Mirshahi MC, Ma Xi, Mirshahi M, Samama M, Caen JP. Specific determination and identification of cross linked fibrin degradation products in patients under thrombolytic therapy for myocardial infarction.
Seminars in Thrombosis and Haemostasis 1987, 1, 223.
[27] Collin JP, Faure JP, Falcon J, Voisin P, Brisson P, Mirshahi M. Pinéale et rétine.
Médecine/Sciences, 1988, 4, 16-26.
[28] Faivre R, Mirshahi Mc, Ducellier D, Soria C, Soria J, Mirshahi M, Kieffer Y, Bassand JP, Maurat JP, Caen JP. Evolution of plasma specific fibrin degradation products during thrombolytic therapy in patients with thromboembolism.
Thrombosis Res. 1988, 50, 583-589.
[29] Mirshahi MC, Soria C, Soria J, Mirshahi M, Faivre R, Kieffer Y, Bassand JP, Toutlemonde F, Caen JP. Change in plasma fibrin degradation products as a marker of thrombus evolution in patients with deep vein thrombosis.
Thrombosis Res., 1988, 51, 295-301.
[30] de Kozak Y, Mirshahi M, Boucheix C, Faure JP. Modulation of experimental autoimmune uveoretinitis by adoptive transfer of cells from rats immunized with anti-S-antigen monoclonal antibody.
Regional Immunol., 1989, 2, 311-320.
[31] Faivre R., Neuhart E., Mirshahi M., Mirshahi M.C., Soria C., Soria J., Bassand J.P., Caen JP, Maurat JP. Fibrinolytic and thrombolytic parameters in patients with deep vein thrombosis treated by low molecular weight and standard heparin.
Seminars in Thrombosis and Haemost. 1989, 15, 435-349.
[32] Mirshahi M, Borgese F, Razaghi A, Scheuring U, Garcia-Romeu F, Faure JP, Motais R. Immunological detection of arrestin, a phototransduction regulatory protein, in the cytosol of nucleated erythrocytes.
FEBS Lett., 1989, 258, 240-243.
[33] Mirshahi M, Mirshahi S, Soria C, Soria J, Thomaidis A, Pouliquen Y, Faure JP. Production of proteases type plasminogen activator and their inhibitor in cornea.
Biochem. Biophys. Res. Comm., 1989, 160, 1021-1025.
[34] de Kozak Y, Mirshahi M. Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression.
Internat. Ophthalmol. 1990, 14, 43-56.
[35] Faure JP, Mirshahi M. S-antigen in non ocular tissues.
Curr. Eye Res., 1990, 9 Suppl., 163-67.
[36] Mirshahi M, Mirshahi S, Soria C, Lorans G, Soria J, Bureau J, Thomaidis A, Pouliquen Y. Sécrétion des activateurs du plasminogène et de leurs inhibiteurs par les fibroblastes de la cornée. Modification de cette sécrétion dans la dystrophie cornéenne cristalline de Schnyder.
C.R. Acad. Sci., Série III ,311, 1990, 253-260.
[37] Mirshahi M, Mirshahi S, Soria C, Perrot JY, Guidalia M, Boucheix C, Soria J. Evolutionary stability of fibrinogen epitopes implicated in fibrin polymerization and in fibrinolysis.
Blood Coagulation and Fibrinolysis, 1990, 1, 427-431.
[38] Scheuring U, Franco M, Fievet B, Guizouarn H, Mirshahi M, Faure JP, Motais R. Arrestin from nucleated red blood cells binds to bovine rhodopsin in a light-dependent manner.
FEBS Lett. 1990,276, 192-196.
[39] Claudy A, Mirshahi M, Soria C, Soria J. Détection of undegraded fibrin and tumor necrosis factor alpha in venous leg ulcers.
J. Am. Acad. Dermatol. 1991, 25, 623-627.
[40] Mirshahi M, de Kozak Y,Tarraf M, Razaghi A, Thillaye B, Faure JP. Early disappearance of alpha-transducin in light-induced photoreceptor degeration in albino rats. Curr. Eye Res., 1991, 10, 993-1000.
[41] Mirshahi M, Nato A, Razaghi A, Mirshahi A, Faure JP. Présence de protéines apparentées à l'arrestine ( antigène- S ) dans des cellules végétales.
C R Acad Sci. Paris, 1991, 312, Série III, 441-448.
[42] Mirshahi M, Razaghi A, Mirshahi S, Tuyen V, Faure JP. Immunopurification of an S-antigen-like protein from human platelets.
Thrombosis Res., 1991, 64, 551 - 558.
[43] Nato F, Goulut C, Mirshahi M, Bourrillon R. Immunological screening of a glycoprotein antigen expressed by Zajdela ascites hematoma cells a normal rat tissues and tumor.
Scand. J. Immunol. 1991, 34, 411-419.
[44] Oliver J, Mirshahi M, Herbuté S, Peraldi- Roux S, Trébuchon L, Brisson P, Collin JP, Faure JP, Gabrion J. Distribution of arrestin-like protein and beta subunit of GTP-binding proteins in quail chroid plexuses.
Cellular Signalling.1991, 3, 461-472.
[45] Mirshahi M, Mirshahi A, Nato A, Agarwal MK. Mineralocorticoid hormone action in plant cells.
Biochem. Biophys. Res. Comm.,1992, 186, 1102-1107.
[46] de Kozak Y, Mirshahi M, Boucheix C, Faure JP. Inhibition of S-antigen-induced experimental autoimmune uveoretinitis by active immunization against anti-idiotypic antibody to an S-antigen epitope.
Regional Immunol., 1992, 4, 168-174.
[47] de Kozak Y, Stiemer RH, Mirshahi M, Frank RW, de Smet M, Faure JP. Humoral immune response against the S-antigen / TNF alpha common epitope in rat EAU suppressed by the monoclonal antibody S2D2.
Curr. Eye Res. 1992, 11 Suppl., 119-126.
[48] Agarwal MK, Mirshahi M. Rat lung possesses the mineralocorticoid receptor.
Biochem. Biophys. Res. Comm.,1992, 183, 405-410.
[49] Mirshahi M, Pagano M, Mirshahi A, Agarwal MK. Generation of polyclonal antibodies against the mineralocorticoid receptor and analysis of mineralocortin in rat myocardium by immunophotochemistry.
Biochem. Biophys. Acta ., 1992; 1120, 17-23.
[50] Mirshahi M, Pagano M, Razaghi A, Lazar G, Agarwal MK. Immunophotochemical analysis of mineralocortinby polyclonal antibodies againstthe native receptor from rat kidny.
Biochem. Med. Metab. Biol., 1992; 47, 133-144.
[51] Mirshahi M, Razaghi A, Vandewalle A, Cluzeaud F, Tarraf M, Faure JP. Immunodetection and localization of protein(s) related to retinal S-antigen (arrestin) in kidney.
Biol. Cell 1992, 76, 175-184.
[52] Mirshahi S, Pujade-Lauraine E, Soria C , Mirshahi M, Frétault J, Bernadou A ,Soria J. D-Dimer and CA-125 levels in patients with ovarian cancer during antineoplastic therapy -Prognostic significance for the success of anticancer treatment.
Cancer, 1992, 69, 2289-2292.
[53] Mirshahi S, Soria J, Lu H, Pujade-Lauraine E, Mirshahi M, Bernadou A, Soria C. Effect of interferon gamma and adriamycine on fibrinolytic activity associated to human monocytes.
Fibrinolysis, 1992, 6, 157-160.
[54] Stiemer RH, Gausepohl H, Mirshahi M, de Kozak Y, Kraft M, Faure JP, Frank RW. Immunological characterization of an immunomodulatory epitope in S-antigen / arrestin with a sequence motif common to tumor necrosis factor alpha.
Immunol. Lett., 1992, 32, 233-240.
[55] Stiemer RH., Westenfelder U, de Kozak Y, Gausepohl H, Mirshahi M, Frank RW, Faure JP, Männel DN. Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha.
Curr. Eye Res. 1992, 11 Suppl., 197-202.
[56] Stiemer RH, Westenfelder U, Gausepohl H, Mirshahi M, Gundt A, Frank RW, Männel DN. A common epitope in human tumor necrosis factor alpha and the autoantigen "S-antigen/arrestin" induces TNFalpha production.
J. Autoimmun.1992, 5, 15-26.
[57] Mirshahi M, Mirshahi A, Nato A, Agarwal MK. Receptor mediated mineralocorticoid action in alga cell mutats
FEBS lett.1992; 314, 237-240.
[58] Mirshahi SS, Vasse M, Soria C,Moreau JF, Taupin JL, Mirshahi M, Pujade-Lauraine E, Bernadou A, Soria J. Incubation of monocytes with adriamycin increases secretion of hepatocyte stimulating factor for fibrinogen biosynthesis and urokinase-associated to cell membrane.
Blood Coagulation and Fibrinolysis 1993 , 4, 149-152.
[59] Vasse M, Mirshahi SS, Soria J, ,Mirshahi M , Borg JY, Monconduit M, Soria C. Potent activity of peripheral lymphocytes on monocytes in induced hepatocyte stimulating factor and urokinase.
Blood Coagulation and Fibrinolysis 1993, 4, 143-149.
[60] Agarwal MK, Mirshahi F, Mirshahi M, Rostene W. Immunochemical detection of the mineralocorticoid receptor in rat brain.
Neuroendocrinology 1993, 58, 575-580.
[61] Mirshahi M, Thillaye B,Tarraf M, deKozak Y, Faure JP. Light-induced changes in S-antigen (arrestin) localization in retinal photorecetors; difference between rods and cones and defective process in RCS rat retinal dystrophy.
Eur. J. Cell Biol. 1994,63, 61-67.
[62] Agarwal MK, Mirshahi M, Braq S, Jullienne A, Leblanc N, Stibon F, Guern J. Nicotiana Tabacum contains a putative mineralocorticoid receptor.
Biochem. Biophys. Res. Comm.,1994 , 200; 1230-1228.
[63] Pagano M, Mirshahi M, Mirshahi F, Monnot M, Lazar G, Chassaing CG, Fermandjian S, Agarwal MK. Properties of the mineralocorticoid receptor immunopurfied from bovin kidney.
Biochem. Pharmacol. 1994; 48, 1163-1169.
[64] Dubertret G, Mirshahi A, Mirshahi M, Gerardhirne C,Tremolieres A. The d3-transe-hexadecenoic acid-containing phoshatidylinoglycerol is involved in the biogenesis of the light-harvesting hlorophyll A/B-protein complex of chlamydomonas reiharditti; evidence for in vivo manupulaions of lipid composition in mutants.
Eur. J. Biochem., 1994, 113, 801-807.
[65] Mirshahi SS, Soria J, Mishal Z, Mirshahi M, Lenoble M, Soria C. Pentoxifilline inhibits calcium mediated activation by tumor necrosis factor in humain monocytes.
Cell. Pharmacol., 1994, 1,63-66.
[66] Mirshahi SS, Soria J. Mirshahi M, Soria C, Lenoble M, Cambazard F, Claudy A. Expression elastase and fibrin in in venous leg ulcer biopsies. A pilot study of pentoxifylline versus placebo.
J. Cardiovasc. Pharmacol. 1995, 25,101-105
[67] Lebrazi J, Abdelouahed M, Mirshahi M, Gouin I, Samama M, Lecompte T. Streptokinase and APSAC inhibit platelet aggregation in vitro by fibrinogenolysis: effet of plasma fibrinogen degradation products X and E.
Fibrinolysis, 1995, 9, 113-119.
[68] Lebrazi J, Helft G, Mirshahi M, Gouin I, Samama M, Lecompte T. Human anti streptokinase antibodies induce platelet aggregation in a FC/CD32 dependent manner.
Thrombosis Hemostasis 1995, 74 938-942.
[69] Lopez-Alemany R, Mirshahi S, Faure JP, Pouliqeun Y, Burtin P, Mirshahi M. Binding of plasminogen to corneal fibroblasts and their extracellular matrix. Evidence for a receptor in cell membranes.
Fibrinolysis, 1995, 9; 223-229 .
[70] Abdelouahed M, Elalamy S, Lebrazi J, Gerard H, Mirshahi M, Leucrubier ., Samama M, Lecompte T. Streptokinase modifies in vitro platelet aggregation by two mechanisms: defect by fibrinogenolysis and activation by immunological reaction.
Platelet 1995, 6; 317-325.
[71] Agarwal MK, Mirshahi F, Mirshahi M, Braq S, Chentoufi J, Julienne A, Marie JP. Receptor mediated physiological action of Mineralocorticoids in rat osteoblastic cells .
Americ. J. Physiol. 1996, 270 (cell physiol 39)C1088-C1095.
[72] Mirshahi , Nicola C, Mirshahi A, Hecquet C, Dhermy F, Faure JP, Agarwal MK. The mineralocorticoid hormone receptor and action in the eye.
Biochem. Biophys. Res. Comm., 1996, 219; 150-156.
[73] Janabi N, Mirshahi A, Wolfrom C, Mirshahi M, Tardieu M. Effect of interferon- γ and TNF- α on the differentiation /activation of humain glial cells; implication for TNF alpha receptor-1
Res. Virol. (Institut Pasteur) 1996, 147; 147-153.
[74] Mirshahi S, Soria J, Nelles L, Soria C, Faure JP, Pouliquen Y, Mirshahi M. Plasminogen activators in human corneal fibroblasts, cellular localization and regulation.
Fibrinolysis 1996, 10, 255-262.
[75] Nato A, Henry Y, De Buyser J,Mirshahi M, Lavergne D, Jean C, Cavalcante-Alves M, Ducreux G , Tichtinsky G, Jouannic S, Hamal A ,Kreis M. Expression of signaling molecules during wheat somatic embryogenesis.
Plant Tissue Culture and Biotechnology. 1996, 2, 212-214.
[76] Mirshahi M, Mirshahi A, Sedighian R, Hecquet C, Faure JP, Agarwal MK. Immunochemical demonstration of the mineralocorticoid receptor in ocular tissues
Neuroendocrinology.1997, 65; 70-78.
[77] Nato A, Mirshahi A, Mirshahi M, Faure JP, Lavergne D, Ducreux G, Henry Y. Signal transduction molecules expressed during wheat differantiation via somatic embryogenesis.
Plant Physiology, 1997, 113; 801-807.
[78] Razaghi A, Bonaly J, Chacun H, Faure JP, Mirshahi M, Barque JPh. Immunodetection of a protein related to mammalian arrestin in Eauglena gracilis.
Biochem. Biophys. Res. Comm. 1997, 233; 601-605.
[79] Nicolas C, Ghedira I, Faure JP, Mirshahi M. Identification of arrestin-like proteins in a human megakaryocytic cell line (HEL cells).
Platelet, 1998, 9; 55-62.
[80] Emadi S, Mirshahi M, Elalamy I, Nicolas C, Vargaftgi BB., Hatmi M. Cellular source of human platelet secretory phospholipase A2
Brit. J. of Hemat. 1998, 100, 365-373.
[82] Mirshahi M, Nicolas C, Agarwal MK.Enhanced activation of the mineralocorticoid receptor in genetically hypertensive rat.
Biochem. Biophys. Res. Comm. 1998, 244, 120-125.
[82] Pouliquen Y, Bureau J, Mirshahi M, Mirshahi SS, Assouline M, Lorens G. Keratoconus and inflammatory processes
Bull Soc Belge Ophtalmol. 1996, 262, 25-28.
[83] Mirshahi M, Mirshahi S, Golestaneh N, Nicolas C Mishal Z, Agarwal MK. Mineralocorticoid hormone receptor and the epithelial sodium channel in a human leukemic cell line.
Endocr. Res.1998, 24, 455-459.
[84] Lafont A, Durand E, Vilde F, Moreyea C, Drechsel S, Mirshahi S, Mirshahi M, Guérot C, Lemarchand P. Thrombus generation after adenovirus-mediated gen transfer into atherosclerotic arteries .
Human Gene Therapy . 1999, 10, 2795-2800.
[85] Nicolas C, Ghedira I, Faure JP, Mirshahi M.
Arrestin -related proteins in ocular tissues.
Inves. Ophtalmol. Vis.Sci. 1999,40, 1812-1818.
[86] Mirshahi M, Nicolas C, Mirshahi S, Golestaneh N, d'Hermies F, Agarwal MK. Immunochemical analysis of the sodium channel in rodent and human eye.
Ex. Eye Res.1999, 69: 21-32.
[87] Mirshahi M, Camoin L, Nicolas C, Ghedira I, Cozette J, Faure JP. Copurification of glycolytic enzymes with retinal S-antigen (arrestin) by hydroxyapatite agarose chromatography of bovine retina.
Curr. Eye Res.1999, 18, 327-334.
[88] Agarwal MK, Mirshahi M. General overview of mineralocorticoid hormone action
Pharmacol.Therap. 1999, 84, 273-326.
[89] Merodio M, Campanero MA., Mirshahi T, Mirshahi M, Irachi JM. Development of a new and sensitive method for the determination of ganciclovir by reversed-phase hirh performance liquid chromatography.
Journal of Chromatography , 2000, 870, 159-167.
[90] Mirshahi M, Golestaneh N, Valamanesh F, Agarwal MK, Paradoxal effects of mineralocorticoids on the ion gate sodium channel in embryologically diverse cells.
Biochem. Biophys. Res. Comm. 2000, 270, 811-815.
[91] Mirshahi M, Mirshahi S, Golestaneh N, Mishal Z, Nicolas C, Hecquet C, and Agarwal MK, Demonstration of the mineralocorticoid hormone receptor and action in human leukemic cell lines
Leukemia , 2000, 14, 1097-1104.
[92] Nicola C, Ghedira I, Stiemer R, Teufel B, Hecquet C, Faure JP, Mirshahi M. Identification of visual arrestin(S-antigen) in retinal pigmented epithelial cells.
Curr Eye Res. 2000, 21, 677-83.
[93] Golestaneh N, Nicolas C, Picaud S, Ferarri P, Mirshahi M. The mineralocorticoid receptor in rodent retina, ontogeny and molecular identity.
Curr Eye Res. 2000, 21, 703-9.
[94] Merodio M, Irache JM, Eclancher F., Mirshahi M., Villarroya H. Distribution of albumin nanoparticles in animals induced with the experimental allergic encephalomyelitis.
J. Drug Target. 2000, 8, 289-303.
[95] Lounes KC, Soria C, Mirshahi SS, Desvignes P, Mirshahi M, Bertrand O, Bonnet P, Koopman J, Soria J. Fibrinogen Ales: a homozygous case of dysfibrinogenemia (gamma-Asp(330)-->Val) characterized by a defective fibrin polymerization site "a".
Blood. 2000, 96, 3473-9.
[96] Mirshahi M, Mirshahi S, Golestaneh N, Nicolas C, Mishal Z, Lounes KC, Hecquet C, Dagonet F, Pouliquen Y, Agarwal MK. Mineralocorticoid hormone signaling regulates the 'epithelial sodium channel' in fibroblasts from human cornea.
Ophthalmic Res. 2001, 33, 7-19.
[97] Golestaneh N, Klein C, Valamanesh F, Suarez G, Agarwal MK, Mirshahi M. Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton.
Biochem Biophys Res Commun. 2001, 280,1300-6.
[98] Golestaneh N, De Kozak Y, Klein C, Mirshahi M. Epithelial sodium channel and the mineralocorticoid receptor in cultured rat Muller glial cells.
Glia. 2001, 33, 160-8.
[99] Gerotziafas GT, Elalamy I, Lecrubier C, Lebrazi J, Mirshahi M, Potevin F, Lecompte T, Samama M.M. The role of platelet factor 4 in platelet aggregation induced by the antibodies implicated in heparin-induced thrombocytopenia.
Blood Coagul Fibrinolysis. 2001, 12, 511-20.
[100] Merodio M, Irache JM, Valamanesh F, Mirshahi M. Ocular disposition and tolerance of ganciclovir-loaded albumin nanoparticles after intravitreal injection in rats
Biomaterials ; 2002, 23, 1587-1594.
[101] Merodio M, Espuleas MS, Mirshahi M, Arendo A, Irache JM. Efficacy of Ganciclovir-loaded Nanoparticles in humain cytomegalovirus (HCMV)-infected cells.
Journa.of Drug Targeting, 2002, 10, 231-238.
[102] Mirshahi M, Ayani E, Nicolas C, Golestaneh N, Ferrari P, Valamanesh F, Agarwal MK. The blockade of mineralocorticoid hormone signaling provokes dramatic teratogenesis in cultured rat embryos.
Int J Toxicol. 2002 , 21, 191-199.
[103] Merodio M, Espuelas MS, Mirshahi M, Arnedo A, Irache JM. Efficacy of ganciclovir-loaded nanoparticles in human cytomegalovirus (HCMV)-infected cells.
J Drug Target. 2002,10, 231-238.
[104] Golestaneh N, Picaud S, Mirshahi M. The mineralocorticoid receptor in rodent retina: Ontogeny and molecular identity
Mol. Vis. 2002, 8,221-225
[105] Chen WM, Zhu J, Mirshahi F, Soria J, Mirshahi M, Soria C. Thalidomide inhibits the angiogenic activity of cutlure supernatants of multiple myeloma cell line.
Zhonghua Xue Ye Xue Za Zhi. 2002, 23, 520-523.
[106] Chen WM, Wu Y, Zhu JZ, Soria J, Mirshahi M. Study on angiogenesis of multiple myeloma in vitro
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002,10, 310-4. Chinese.
[107] Mirshahi T, Irache JM, Nicolas C, Mirshahi M, Faure JP, Geugen J, Hequet C, Orechioni AM, Adoptive immune responses of legumin nanoparticles
J. Drug targeting 2002, 10, 625-631.
[108] Vincent S, Mirshahi M, Nicolas C, Adenis C, Dhellemes P, Soto Ares G, Maurage CA, Baranzelli MC, Giangaspero F, Ruchoux MM. Larg – cell medulloblastoma with arrestin-like protein expression.
Clin.Neuropath., 2003, 22, 1-9 .
[109] Lopez-Alemany R, Longstaff C, Hawley S, Mirshahi M, Fabregas P, Jardi M, Merton E, Miles LA, Felez J. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase.
Am J Hematol. 2003,72, 234-242.
[110] Mirshahi M, Agarwal MK. Receptor- mediated adrenocorticoid hormone signaling in ocular tissues.
Biochem. Pharmacol.2003; 65/8 pp 1207 - 1214
[111] Mirshahi M, valamanesh F, Golestaneh N, Mirshahi P, Vincent L, tang R, Agarwal MK. Mineralocorticoid hormones exert dramatic effects on pluripotent human stem cell progeny.
Int J Toxicol. 2003, 22, 297-304.
[112] Chen W, Valamanesh F,
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